Acute Bacterial, Nonnecrotizing Cellulitis in Finland: Microbiological Findings
Identifieur interne : 006C85 ( Main/Exploration ); précédent : 006C84; suivant : 006C86Acute Bacterial, Nonnecrotizing Cellulitis in Finland: Microbiological Findings
Auteurs : Tuula Siljander [Finlande] ; Matti Karppelin [Finlande] ; Susanna V H Kuopus ; Jaana Syrj Nen [Finlande] ; Maija Toropainen ; Juha Kere [Suède] ; Risto Vuento [Finlande] ; Tapio Jussila [Finlande] ; Jaana Vuopio-VarkilaSource :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2008-03-15.
Abstract
Background. Bacterial, nonnecrotizing cellulitis is a localized and often recurrent infection of the skin. The aim of this study was to identify the β-hemolytic streptococci that cause acute nonnecrotizing cellulitis infection in Finland. Methods. A case-control study of 90 patients hospitalized for acute cellulitis and 90 control subjects was conducted during the period of April 2004–March 2005. Bacterial swab samples were obtained from skin lesions or any abrasion or fissured toe web. Blood culture samples were taken for detection of bacteremia. The patients, their household members, and control subjects were assessed for pharyngeal carrier status. β-Hemolytic streptococci and Staphylococcus aureus were isolated and identified, and group A and G streptococcal isolates were further analyzed by T serotyping and emm and pulsed-field gel electrophoresis typing. Results. β-Hemolytic streptococci were isolated from 26 (29%) of 90 patients, 2 isolates of which were blood-culture positive for group G streptococci, and 24 patients had culture-positive skin lesions. Group G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis) was found most often and was isolated from 22% of patient samples of either skin lesions or blood, followed by group A Streptococcus, which was found in 7% of patients. Group G streptococci were also carried in the pharynx of 7% of patients and 13% of household members but was missing from control subjects. Several emm and pulsed-field gel electrophoresis types were present among the isolates. Six patients (7%) had recurrent infections during the study. In 2 patients, the group G streptococcal isolates recovered from skin lesions during 2 consecutive episodes had identical emm and pulsed-field gel electrophoresis types. Conclusions. Group G streptococci, instead of group A streptococci, predominated in bacterial cellulitis. No clear predominance of a specific emm type was seen. The recurrent nature of cellulitis became evident during this study.
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DOI: 10.1086/527388
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J" first="Juha" last="Kere">Juha Kere</name></author><author><name sortKey="Vuento, Risto" sort="Vuento, Risto" uniqKey="Vuento R" first="Risto" last="Vuento">Risto Vuento</name></author><author><name sortKey="Jussila, Tapio" sort="Jussila, Tapio" uniqKey="Jussila T" first="Tapio" last="Jussila">Tapio Jussila</name></author><author><name sortKey="Vuopio Varkila, Jaana" sort="Vuopio Varkila, Jaana" uniqKey="Vuopio Varkila J" first="Jaana" last="Vuopio-Varkila">Jaana Vuopio-Varkila</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:862F6855D8189C1AE91AFADD815C5545F35EE7A8</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1086/527388</idno><idno type="url">https://api.istex.fr/document/862F6855D8189C1AE91AFADD815C5545F35EE7A8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003F35</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003F35</idno><idno 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Karppelin</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine, Tampere University Hospital, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="V H Kuopus, Susanna" sort="V H Kuopus, Susanna" uniqKey="V H Kuopus S" first="Susanna" last="V H Kuopus">Susanna V H Kuopus</name><affiliation><wicri:noCountry code="subField">Helsink</wicri:noCountry></affiliation></author><author><name sortKey="Syrj Nen, Jaana" sort="Syrj Nen, Jaana" uniqKey="Syrj Nen J" first="Jaana" last="Syrj Nen">Jaana Syrj Nen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine, Tampere University Hospital, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Toropainen, Maija" sort="Toropainen, Maija" uniqKey="Toropainen M" first="Maija" last="Toropainen">Maija Toropainen</name><affiliation><wicri:noCountry code="subField">Helsink</wicri:noCountry></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Vuento, Risto" sort="Vuento, Risto" uniqKey="Vuento R" first="Risto" last="Vuento">Risto Vuento</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Jussila, Tapio" sort="Jussila, Tapio" uniqKey="Jussila T" first="Tapio" last="Jussila">Tapio Jussila</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Hatanpää City Hospital, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Vuopio Varkila, Jaana" sort="Vuopio Varkila, Jaana" uniqKey="Vuopio Varkila J" first="Jaana" last="Vuopio-Varkila">Jaana Vuopio-Varkila</name><affiliation><wicri:noCountry code="subField">Helsink</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2008-03-15">2008-03-15</date><biblScope unit="volume">46</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="855">855</biblScope><biblScope unit="page" 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Bacterial, nonnecrotizing cellulitis is a localized and often recurrent infection of the skin. The aim of this study was to identify the β-hemolytic streptococci that cause acute nonnecrotizing cellulitis infection in Finland. Methods. A case-control study of 90 patients hospitalized for acute cellulitis and 90 control subjects was conducted during the period of April 2004–March 2005. Bacterial swab samples were obtained from skin lesions or any abrasion or fissured toe web. Blood culture samples were taken for detection of bacteremia. The patients, their household members, and control subjects were assessed for pharyngeal carrier status. β-Hemolytic streptococci and Staphylococcus aureus were isolated and identified, and group A and G streptococcal isolates were further analyzed by T serotyping and emm and pulsed-field gel electrophoresis typing. Results. β-Hemolytic streptococci were isolated from 26 (29%) of 90 patients, 2 isolates of which were blood-culture positive for group G streptococci, and 24 patients had culture-positive skin lesions. Group G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis) was found most often and was isolated from 22% of patient samples of either skin lesions or blood, followed by group A Streptococcus, which was found in 7% of patients. Group G streptococci were also carried in the pharynx of 7% of patients and 13% of household members but was missing from control subjects. Several emm and pulsed-field gel electrophoresis types were present among the isolates. Six patients (7%) had recurrent infections during the study. In 2 patients, the group G streptococcal isolates recovered from skin lesions during 2 consecutive episodes had identical emm and pulsed-field gel electrophoresis types. Conclusions. Group G streptococci, instead of group A streptococci, predominated in bacterial cellulitis. No clear predominance of a specific emm type was seen. The recurrent nature of cellulitis became evident during this study.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>Suède</li></country></list><tree><noCountry><name sortKey="Toropainen, Maija" sort="Toropainen, Maija" uniqKey="Toropainen M" first="Maija" last="Toropainen">Maija Toropainen</name><name sortKey="V H Kuopus, Susanna" sort="V H Kuopus, Susanna" uniqKey="V H Kuopus S" first="Susanna" last="V H Kuopus">Susanna V H Kuopus</name><name sortKey="Vuopio Varkila, Jaana" sort="Vuopio Varkila, Jaana" uniqKey="Vuopio Varkila J" first="Jaana" last="Vuopio-Varkila">Jaana Vuopio-Varkila</name></noCountry><country name="Finlande"><noRegion><name sortKey="Siljander, Tuula" sort="Siljander, Tuula" uniqKey="Siljander T" first="Tuula" last="Siljander">Tuula Siljander</name></noRegion><name sortKey="Jussila, Tapio" sort="Jussila, Tapio" uniqKey="Jussila T" first="Tapio" last="Jussila">Tapio Jussila</name><name sortKey="Karppelin, Matti" sort="Karppelin, Matti" uniqKey="Karppelin M" first="Matti" last="Karppelin">Matti Karppelin</name><name sortKey="Syrj Nen, Jaana" sort="Syrj Nen, Jaana" uniqKey="Syrj Nen J" first="Jaana" last="Syrj Nen">Jaana Syrj Nen</name><name sortKey="Vuento, Risto" sort="Vuento, Risto" uniqKey="Vuento R" first="Risto" last="Vuento">Risto Vuento</name></country><country name="Suède"><noRegion><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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